Thermodynamic analysis of hybridization between POPNA and DNA

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Thermodynamic analysis of hybridization between POPNA and DNA.

We have developed a new series of oxy-peptide nucleic acids with pyrrolidine rings of four different types of structural isomers (cis L, cis D, trans L, trans D configurations; POPNAs). Melting curves of adenine nanomers of POPNAs in the presence of the complementary DNA showed the highest Tm value for cis L-POPNA, but in the case of RNA, the highest Tm value was observed for trans L-POPNA. The...

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ژورنال

عنوان ژورنال: Nucleic Acids Symposium Series

سال: 2002

ISSN: 0261-3166,1746-8272

DOI: 10.1093/nass/2.1.261